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[PDF] Gram Positive Phages From Isolation To Application Download

Gram positive phages  From isolation to application PDF
Author: Jennifer Mahony
Publisher: Frontiers Media SA
ISBN: 2889194930
Size: 67.58 MB
Format: PDF, ePub
Category :
Languages : en
Pages :
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Gram Positive Phages From Isolation To Application

by Jennifer Mahony, Gram Positive Phages From Isolation To Application Books available in PDF, EPUB, Mobi Format. Download Gram Positive Phages From Isolation To Application books, Phage biology is one of the most significant and fundamental aspects of biological research and is often used as a platform for model studies relating to more complex biological entities. For this reason, phage biology has enjoyed focused attention and significant advances have been made in the areas of phage genomics, transcriptomics and the development and characterisation of phage-resistance mechanisms. In recent years, considerable research has been performed to increase our understanding of the interactions of these phages with their hosts using genomic, biochemical and structural approaches. Such multidisciplinary approaches are core to developing a full understanding of the processes that govern phage infection, information that may be harnessed to develop anti-phage strategies that may be applied in food fermentations or applied in a positive sense in phage therapy applications. The co-evolutionary processes of these phages and their hosts have also been a considerable focus of research in recent years. Such data has promoted a deeper understanding of the means by which these phages attach to and infect their hosts and permitted the development of effective anti-phage strategies. Furthermore, the presence and activity of host-encoded phage-resistance systems that operate at various stages of the phage cycle and the potential for the application of such systems consolidates the value of research in this area. Conversely, phages and their components have been applied as therapeutic agents against a number of pathogens including, among others, Clostridium difficile, Lactococcus garviae, Mycobacterium spp., Listeria spp. and the possibilities and limitations of these systems will be explored in this topic. Additionally, phage therapeutic approaches have been applied to the prevention of development of food spoilage organisms in the brewing and beverage sectors and exhonorate the positive applications of phages in the industrial setting. This research topic is aimed to address the most current issues as well as the most recent advances in the research of phages infecting Gram-positive bacteria covering areas such as phages in food fermentations, their impact in industry, phage ecology, genomics, evolution, structural analysis, phage-host interactions and the application of phages and components thereof as therapeutic agents against human and animal pathogens.


[PDF] Phage Therapy Past Present And Future Download

Phage Therapy  Past  Present and Future PDF
Author: Stephen T. Abedon
Publisher: Frontiers Media SA
ISBN: 2889452514
Size: 49.79 MB
Format: PDF, Kindle
Category :
Languages : en
Pages :
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Phage Therapy Past Present And Future

by Stephen T. Abedon, Phage Therapy Past Present And Future Books available in PDF, EPUB, Mobi Format. Download Phage Therapy Past Present And Future books, Historically, the first observation of a transmissible lytic agent that is specifically active against a bacterium (Bacillus anthracis) was by a Russian microbiologist Nikolay Gamaleya in 1898. At that time, however, it was too early to make a connection to another discovery made by Dmitri Ivanovsky in 1892 and Martinus Beijerinck in 1898 on a non-bacterial pathogen infecting tobacco plants. Thus the viral world was discovered in two of the three domains of life, and our current understanding is that viruses represent the most abundant biological entities on the planet. The potential of bacteriophages for infection treatment have been recognized after the discoveries by Frederick Twort and Felix d’Hérelle in 1915 and 1917. Subsequent phage therapy developments, however, have been overshadowed by the remarkable success of antibiotics in infection control and treatment, and phage therapy research and development persisted mostly in the former Soviet Union countries, Russia and Georgia, as well as in France and Poland. The dramatic rise of antibiotic resistance and especially of multi-drug resistance among human and animal bacterial pathogens, however, challenged the position of antibiotics as a single most important pillar for infection control and treatment. Thus there is a renewed interest in phage therapy as a possible additive/alternative therapy, especially for the infections that resist routine antibiotic treatment. The basis for the revival of phage therapy is affected by a number of issues that need to be resolved before it can enter the arena, which is traditionally reserved for antibiotics. Probably the most important is the regulatory issue: How should phage therapy be regulated? Similarly to drugs? Then the co-evolving nature of phage-bacterial host relationship will be a major hurdle for the production of consistent phage formulae. Or should we resort to the phage products such as lysins and the corresponding engineered versions in order to have accurate and consistent delivery doses? We still have very limited knowledge about the pharmacodynamics of phage therapy. More data, obtained in animal models, are necessary to evaluate the phage therapy efficiency compared, for example, to antibiotics. Another aspect is the safety of phage therapy. How do phages interact with the immune system and to what costs, or benefits? What are the risks, in the course of phage therapy, of transduction of undesirable properties such as virulence or antibiotic resistance genes? How frequent is the development of bacterial host resistance during phage therapy? Understanding these and many other aspects of phage therapy, basic and applied, is the main subject of this Topic.


[PDF] Dictionary Of Dna And Genome Technology Download

Dictionary of DNA and Genome Technology PDF
Author: Paul Singleton
Publisher: John Wiley & Sons
ISBN: 1118447549
Size: 48.66 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 528
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Dictionary Of Dna And Genome Technology

by Paul Singleton, Dictionary Of Dna And Genome Technology Books available in PDF, EPUB, Mobi Format. Download Dictionary Of Dna And Genome Technology books, DNA technology is evolving rapidly, with new methods and a fast-growing vocabulary. This unique dictionary offers current, detailed and accessible information on DNA technology to lecturers, researchers and students throughout the biomedical and related sciences. The third edition is a major update, with over 3000 references from mainstream journals and data from the very latest research – going well beyond the remit of most science dictionaries. It provides clear explanations of terms, techniques, and tests, including commercial systems, with detailed coverage of many important procedures and methods, and includes essay-style entries on many major topics to assist newcomers to the field. It covers topics relevant to medicine (diagnosis, genetic disorders, gene therapy); veterinary science; biotechnology; biochemistry; pharmaceutical science/drug development; molecular biology; microbiology; epidemiology; genomics; environmental science; plant science/agriculture; taxonomy; and forensic science.


[PDF] Bacterial And Bacteriophage Genetics Download

Bacterial and Bacteriophage Genetics PDF
Author: Edward A. Birge
Publisher: Springer Science & Business Media
ISBN: 9780387987309
Size: 32.56 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 559
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Bacterial And Bacteriophage Genetics

by Edward A. Birge, Bacterial And Bacteriophage Genetics Books available in PDF, EPUB, Mobi Format. Download Bacterial And Bacteriophage Genetics books, A comprehensive introduction to this rapidly advancing subject. This fourth edition has been extensively revised and reorganized to reflect advances in the field. All of the major topics in modern bacterial and bacteriophage genetics are presented, including mutations and mutagenesis; genetics of lytic and temperate bacterial viruses; transduction; genetic transformation; conjugation and plasmids; regulatory systems; recombination and repair; probability analysis in bacterial genetic experiments; applied basic genetics; evolutionary genetics. This new edition includes a greater discussion of evolutionary issues and contains problem sets at the ends of each chapter to test students'understanding.


[PDF] Virology Download

Virology PDF
Author: John Carter
Publisher: John Wiley & Sons
ISBN: 0470023864
Size: 21.58 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 358
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Virology

by John Carter, Virology Books available in PDF, EPUB, Mobi Format. Download Virology books, Virology is a clear and accessible introduction to this fast moving field, providing a comprehensive resource enabling students to understand the key concepts surrounding this exciting subject. The authors have produced a text that stimulates and encourages the student through the extensive use of clear, colour-coded diagrams. Taking a modern approach to the subject, the relevance of virology to everyday life is clearly emphasised and discussion on emerging viruses, cancer, vaccines, anti-viral drugs gene vectors and pesticides is included. This title: Provides an introduction to the theories behind the origins of viruses and how they are evolving with discussion on emerging viruses Includes numerous diagrams with standard colour coding for different types of molecule such as DNA, messenger RNA, other virus RNA’s proteins – all diagrams are carefully developed and clearly labelled to enhance student understanding Features self-contained descriptions of the complete replication cycles of a selection of viruses Introduces the relevance of virology to the modern world including the latest developments in the field - HIV, Foot and Mouth disease, Ebola, SARS and MMR Presents summary boxes, further reading and an associated website to include the latest developments Virology is an essential textbook for all undergraduate students of biology, microbiology and biomedical sciences taking courses in virology. It is also an invaluable resource for MSc level students who have previously done little or no virology and are looking for an accessible introduction to the subject.


[PDF] Methods In Microbiology Download

Methods in Microbiology PDF
Author:
Publisher: Academic Press
ISBN: 9780080860404
Size: 68.25 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 312
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Methods In Microbiology

by , Methods In Microbiology Books available in PDF, EPUB, Mobi Format. Download Methods In Microbiology books, Methods in Microbiology


[PDF] The Bacterial Cell Wall Download

The Bacterial Cell Wall PDF
Author: Milton Robert James Salton
Publisher: Springer Science & Business Media
ISBN: 9783540426080
Size: 58.52 MB
Format: PDF
Category : Science
Languages : en
Pages : 280
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The Bacterial Cell Wall

by Milton Robert James Salton, The Bacterial Cell Wall Books available in PDF, EPUB, Mobi Format. Download The Bacterial Cell Wall books, The bacterial cell wall plays an important role in the interaction between bacteria and their environment. Thus, knowledge of the cell wall structure helps us to understand the biological properties. This volume presents a comprehensive description of all main cell wall components of both gram-negative and -positive bacteria (including mycobacteria) and archaea. Surface components outside of the cell wall, i.e. capsules, S-layers, and appendices (flagellae, fimbriae, pili), are discussed and the genetic background of their chemical structures is elucidated. On the basis of the structural background, the biological properties are explained. Methodological topics are also presented and critically discussed.


[PDF] Principles Of Molecular Virology Download

Principles of Molecular Virology PDF
Author: Alan Cann
Publisher: Elsevier
ISBN: 9780120887897
Size: 22.32 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 352
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Principles Of Molecular Virology

by Alan Cann, Principles Of Molecular Virology Books available in PDF, EPUB, Mobi Format. Download Principles Of Molecular Virology books, The fourth edition of the hugely successful Principles of Molecular Virology takes on a molecular approach, presenting the principles of virology in a clear and concise manner. This work explores and explains the fundamental aspects of virology, including structure of virus particles and genome, replication, gene expression, infection, pathogenesis and subviral agents. The self-assessment questions, glossary and abbreviations section provide excellent revision aids and serve as handy references to students, tutors and researchers alike. NEW TO FOURTH EDITION: * New material on virus structure and virus evolution * Updated pathogenesis section covering Ebola, SARS and HIV * New section on Bioterrorism * Fully updated references * New material on virus structure, virus evolution, zoonoses, bushmeat, SARS and bioterrorism


[PDF] The Brucella Phages Download

The Brucella phages PDF
Author: Michael J. Corbel
Publisher:
ISBN:
Size: 34.40 MB
Format: PDF, ePub, Docs
Category : Bacteriophage typing
Languages : en
Pages : 106
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The Brucella Phages

by Michael J. Corbel, The Brucella Phages Books available in PDF, EPUB, Mobi Format. Download The Brucella Phages books,


[PDF] Fields Virology Download

Fields  Virology PDF
Author: David Mahan Knipe
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781760607
Size: 62.76 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 3177
View: 4736

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Fields Virology

by David Mahan Knipe, Fields Virology Books available in PDF, EPUB, Mobi Format. Download Fields Virology books, Accompanying CD-ROM has same title as book.